Transcriptomics

Dataset Information

4

Microarray-based transcription profiling of Streptococcus pneumoniae R6 delta rgtA ,delta rgtD and delta cpoA


ABSTRACT: Alterations in genes for penicillin-binding proteins (pbp) are well-known determinants for the resistance of Streptococcus pneumoniae to B-lactam antibiotics. Surprisingly, some mutations in non-pbp genes were also found to contribute to B-lactam resistance. Two of them discovered in the piperacillin resistant mutants P106 and P104, affect the expression of cpoA (encoding a glycosyltransferase) and of the rgtABCDHR cluster (encoding two small membrane proteins, an ABC transporter and a regulatory two-component system), respectively. cpoA and rgtABCDHR are involved in maintaining the synthesis and the proper ratio of the two major membrane glycolipids, and deletions in these genes led to complex phenotypes. In attempts to identify genetic determinants for these phenotypes, the global trancription patterns of the deletion mutants R6 delta cpoA, R6 delta rgtA and R6 delta rgtD were compared to that of the parent strain R6.

ORGANISM(S): Streptococcus pneumoniae  

SUBMITTER: Martin Rieger  

PROVIDER: E-MEXP-2923 | ArrayExpress | 2011-04-02

REPOSITORIES: ArrayExpress

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