Transcriptomics

Dataset Information

5

Transciption profiling of Burkholderia cenocepacia K56-2 and shvR mutant


ABSTRACT: Transcriptome comparison of Burkholderia cenocepacia K56-2 and shvR (BCAS0225) mutant

ORGANISM(S): Burkholderia cenocepacia  

SUBMITTER: Eoin O'Grady  

PROVIDER: E-MEXP-2939 | ArrayExpress | 2010-11-08

REPOSITORIES: ArrayExpress

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Publications

The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes.

O'Grady Eoin P EP   Nguyen David T DT   Weisskopf Laure L   Eberl Leo L   Sokol Pamela A PA  

Journal of bacteriology 20101022 1


Burkholderia cenocepacia is a significant opportunistic pathogen in individuals with cystic fibrosis. ShvR, a LysR-type transcriptional regulator, has previously been shown to influence colony morphology, biofilm formation, virulence in plant and animal infection models, and some quorum-sensing-dependent phenotypes. In the present study, it was shown that ShvR negatively regulates its own expression, as is typical for LysR-type regulators. The production of quorum-sensing signal molecules was de  ...[more]

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