Dataset Information


P53 binding in H24 cell line

ABSTRACT: Effects of p53 acetylation at the C terminal domain on p53 binding

ORGANISM(S): Homo sapiens  

SUBMITTER: Idit Shiff  

PROVIDER: E-MEXP-3027 | ArrayExpress | 2011-08-01


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DECOD: fast and accurate discriminative DNA motif finding.

Huggins Peter P   Zhong Shan S   Shiff Idit I   Beckerman Rachel R   Laptenko Oleg O   Prives Carol C   Schulz Marcel H MH   Simon Itamar I   Bar-Joseph Ziv Z  

Bioinformatics (Oxford, England) 20110712 17

Motif discovery is now routinely used in high-throughput studies including large-scale sequencing and proteomics. These datasets present new challenges. The first is speed. Many motif discovery methods do not scale well to large datasets. Another issue is identifying discriminative rather than generative motifs. Such discriminative motifs are important for identifying co-factors and for explaining changes in behavior between different conditions.To address these issues we developed a method for  ...[more]

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