Transcriptomics

Dataset Information

30

ApoEdpL-W treatment


ABSTRACT: We performed a gene expression analysis of C. albicans SC5314 planktonic cells exposed to the antifungal peptide ApoEdpL-W. Exponentially-growing C. albicans SC5314 cells in SD at 30°C medium were exposed to 2.5 µM ApoEdpL-W and samples were collected after 10 and 30 min. for transcript profiling

ORGANISM(S): Candida albicans  

SUBMITTER: Tristan Rossignol   

PROVIDER: E-MEXP-3084 | ArrayExpress| 2014-05-02

REPOSITORIES: ArrayExpress

altmetric image

Publications

Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.

Rossignol Tristan T   Kelly Bridie B   Dobson Curtis C   d'Enfert Christophe C  

Antimicrobial agents and chemotherapy 20110801 10


The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms, possibly because of its affinity for extracellular matrix beta-glucans. Moreover, ApoEdpL-W absorbed to medically relevant materials partially prevented the formation of biofilms o  ...[more]

Similar Datasets

2014-05-02 | E-MEXP-3534 | ArrayExpress
2014-05-02 | E-GEOD-10689 | ArrayExpress
2014-05-02 | E-MEXP-3437 | ArrayExpress
2014-05-02 | E-MEXP-3438 | ArrayExpress
2014-05-02 | E-MEXP-3083 | ArrayExpress
2014-05-02 | E-MEXP-3085 | ArrayExpress
2014-05-02 | E-MEXP-2604 | ArrayExpress
2014-05-01 | E-GEOD-19552 | ArrayExpress
2014-05-02 | E-GEOD-29128 | ArrayExpress
2014-05-02 | E-GEOD-8166 | ArrayExpress