Dataset Information


ApoEdpL-W treatment

ABSTRACT: We performed a gene expression analysis of C. albicans SC5314 planktonic cells exposed to the antifungal peptide ApoEdpL-W. Exponentially-growing C. albicans SC5314 cells in SD at 30°C medium were exposed to 2.5 µM ApoEdpL-W and samples were collected after 10 and 30 min. for transcript profiling

ORGANISM(S): Candida albicans  

SUBMITTER: Tristan Rossignol  

PROVIDER: E-MEXP-3084 | ArrayExpress | 2011-04-01


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Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.

Rossignol Tristan T   Kelly Bridie B   Dobson Curtis C   d'Enfert Christophe C  

Antimicrobial agents and chemotherapy 20110801 10

The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms, possibly because of its affinity for extracellular matrix beta-glucans. Moreover, ApoEdpL-W absorbed to medically relevant materials partially prevented the formation of biofilms o  ...[more]

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