Dataset Information


Transcription profiling by array of human osteosarcoma cell lines with phorbol myristate acetate exposure and FOXK2 depletion by siRNA

ABSTRACT: Expression profiling was done of exposure to phorbol myristate acetate -PMA and FOXK2 depletion by siRNA transfection. This was done on the human osteosarcoma U2OS cell line which stably expresses FOXK2. PMA is an inducer of AP1 activity.

ORGANISM(S): Homo sapiens  


PROVIDER: E-MEXP-3107 | ArrayExpress | 2011-11-03


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E-MEXP-3107.README.txt Txt
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The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

Ji Zongling Z   Donaldson Ian J IJ   Liu Jingru J   Hayes Andrew A   Zeef Leo A H LA   Sharrocks Andrew D AD  

Molecular and cellular biology 20111114 2

The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in combinatorial transcriptional control with the AP-1 transcription factor. FOXK2 binding regions are widespread throughout the genome and are often coassociated with AP-1 bi  ...[more]

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