Dataset Information


MiR-21 OVA Lung

ABSTRACT: Lungs from miR-21+/+ and miR-21-/- mice sensitized with OVA/Alum and challenged with either saline or OVA.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Thomas Lu  

PROVIDER: E-MEXP-3119 | ArrayExpress | 2011-08-25


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MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity.

Lu Thomas X TX   Hartner Jochen J   Lim Eun-Jin EJ   Fabry Victoria V   Mingler Melissa K MK   Cole Eric T ET   Orkin Stuart H SH   Aronow Bruce J BJ   Rothenberg Marc E ME  

Journal of immunology (Baltimore, Md. : 1950) 20110817 6

An altered balance between Th1 and Th2 cytokines is responsible for a variety of immunoinflammatory disorders such as asthma, yet the role of posttranscriptional mechanisms, such as those mediated by microRNAs (miRs), in adjusting the relative magnitude and balance of Th cytokine expression have been largely unexplored. In this study, we show that miR-21 has a central role in setting a balance between Th1 and Th2 responses to Ags. Targeted ablation of miR-21 in mice led to reduced lung eosinophi  ...[more]

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