Transcriptomics

Dataset Information

6

Global profiling of platinum drugs resistant genes in A549 cell lines


ABSTRACT: Non Small Cell Lung Cancer (NSCLC) causes the premature death of over 1 million people worldwide each year, but remains inadequately understood at the molecular level. To provide new insights for NSCLC treatment we performed a molecular characterisation of wild type and platinum drugs resistance in A549 cells. Transcriptome profiling revealed contrasting patterns of gene expression in sensitive and resistant cells and identified genes whose expression was highly correlated with the platinum drugs. Our results revealed a gene set of 15 transcripts whose expression was highly correlated with platinum-resistance in NSCLC A549 cell lines.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Colon Cancer,Non-small Cell Lung Carcinoma

SUBMITTER: lin cao  

PROVIDER: E-MEXP-3123 | ArrayExpress | 2012-02-24

REPOSITORIES: ArrayExpress

Similar Datasets

2015-07-07 | E-GEOD-70540 | ArrayExpress
2009-01-14 | E-GEOD-13525 | ArrayExpress
2009-04-30 | E-GEOD-7035 | ArrayExpress
2011-05-05 | E-GEOD-29077 | ArrayExpress
2008-06-14 | E-GEOD-6410 | ArrayExpress
2009-09-13 | E-GEOD-17307 | ArrayExpress
2013-06-10 | E-GEOD-43966 | ArrayExpress
2008-06-16 | E-GEOD-8961 | ArrayExpress
2013-09-15 | E-GEOD-48036 | ArrayExpress
2014-04-04 | E-GEOD-48244 | ArrayExpress