Transcriptomics

Dataset Information

7

Interaction between diabetes and hypertension in a rat model of diabetic nephropathy


ABSTRACT: Fisher male Cyp1a1mRen2 rats were allocated into four groups of four biological replicates each: control; streptozotocin-induced diabetes alone; indole-3-carbinol induced hypertension alone; combined induced diabetes and hypertension.
Kidneys were harvested for microarray analysis.analysis.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Donald R Dunbar  

PROVIDER: E-MEXP-3165 | ArrayExpress | 2011-12-31

REPOSITORIES: ArrayExpress

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Publications

Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.

Conway Bryan R BR   Rennie Jillian J   Bailey Matthew A MA   Dunbar Donald R DR   Manning Jonathan R JR   Bellamy Christopher O CO   Hughes Jeremy J   Mullins John J JJ  

Journal of the American Society of Nephrology : JASN 20111222 3


Rodent models exhibit only the earliest features of human diabetic nephropathy, which limits our ability to investigate new therapies. Hypertension is a prerequisite for advanced diabetic nephropathy in humans, so its rarity in typical rodent models may partly explain their resistance to nephropathy. Here, we used the Cyp1a1mRen2 rat, in which the murine renin-2 gene is incorporated under the Cytochrome P4501a1 promoter. In this transgenic strain, administration of low-dose dietary indole-3-carb  ...[more]

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