Dataset Information


Yap5-mediated transcriptional response to iron

ABSTRACT: Transcriptional response of S. cerevisiae to iron excess and Yap5 targets under high iron growth conditions.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Laura Carreto  

PROVIDER: E-MEXP-3193 | ArrayExpress | 2012-01-30


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The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.

Pimentel Catarina C   Vicente Cristina C   Menezes Regina Andrade RA   Caetano Soraia S   Carreto Laura L   Rodrigues-Pousada Claudina C  

PloS one 20120516 5

The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the i  ...[more]

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