Transcriptomics

Dataset Information

3

Genome-wide Gene Expression profiles of Kashin-Beck Disease


ABSTRACT: We compared genome-wide gene expression profiles of articular cartilage derived from 4 KBD patients and 4 normal controls. Total RNA was isolated from cartilage samples following by being amplified, labeled and hybridized to Agilent human 1A 22k microarray chip(G4110B).

ORGANISM(S): Homo sapiens  

DISEASE(S): Kashin-beck Disease,Normal

SUBMITTER: Feng Zhang  

PROVIDER: E-MEXP-3196 | ArrayExpress | 2011-10-01

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-3196.README.txt Txt
E-MEXP-3196.eSet.r Other
E-MEXP-3196.idf.txt Idf
E-MEXP-3196.processed.1.zip Processed
E-MEXP-3196.raw.1.zip Raw
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Publications

Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease.

Zhang Feng F   Guo Xiong X   Wang Weizhuo W   Yan Hua H   Li Chunyan C  

PloS one 20110729 7


Kashin-Beck Disease (KBD) is an endemic osteochondropathy, the pathogenesis of which remains unclear now. In this study, we compared gene expression profiles of articular cartilage derived respectively from KBD patients and normal controls. Total RNA were isolated, amplified, labeled and hybridized to Agilent human 1A 22 k whole genome microarray chip. qRT-PCR was conducted to validate our microarray data. We detected 57 up-regulated genes (ratios ≥2.0) and 24 down-regulated genes (ratios ≤0.5)  ...[more]

Publication: 1/2

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