Transcriptomics

Dataset Information

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Transcription profiling by array of human oligodendroglioma tumor samples with IDH1 and IDH2 mutations


ABSTRACT: To study the effects of IDH mutations, we collected and performed gene expression microarray analysis with tumor specimens from patients with grade II-III oligodendroglioma. Sequencing for mutations of IDH1 and IDH2 was done. Gene expression was compared between IDH wildtype vs. mutant samples

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Oligodendroglioma

SUBMITTER: Chao Lu  

PROVIDER: E-MEXP-3239 | ArrayExpress | 2012-02-01

REPOSITORIES: ArrayExpress

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Publications


Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel enzymatic property of producing 2-hydroxyglutarate (2HG) from α-ketoglutarate. Here we report that 2HG-producing IDH mutants can prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells. In tumour samples from glioma patients, IDH mutations were  ...[more]

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