Dataset Information


Transcription profiling by array of Saccharomyces cerevisiae to study Met4 hyperactivation over a timecourse in met31 single-deletion and met32 single-deletion strains compared to Met31/Met32 wild-type strains

ABSTRACT: The met31 single delete and the met32 single delete strains were analyzed for genome-wide transcription at different times following Met4 hyeractivation and compared to cells that contain both Met31 and Met32.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Traci A Lee  

PROVIDER: E-MEXP-3301 | ArrayExpress | 2011-08-21


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Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.

Carrillo Emilio E   Ben-Ari Giora G   Wildenhain Jan J   Tyers Mike M   Grammentz Dilon D   Lee Traci A TA  

Molecular biology of the cell 20120321 10

Yeast sulfur metabolism is transcriptionally regulated by the activator Met4. Met4 lacks DNA-binding ability and relies on interactions with Met31 and Met32, paralogous proteins that bind the same cis-regulatory element, to activate its targets. Although Met31 and Met32 are redundant for growth in the absence of methionine, studies indicate that Met32 has a prominent role over Met31 when Met30, a negative regulator of Met4 and Met32, is inactive. To characterize different roles of Met31 and Met3  ...[more]

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