Dataset Information


Transcription profiling of intramacrophage Burkholderia cenocepacia K56-2

ABSTRACT: Effect of internalization by macrophages on bacterial gene transcription in Burkholderia cenocepacia

ORGANISM(S): Burkholderia cenocepacia  

SUBMITTER: Jennifer Tolman   Miguel Valvano  

PROVIDER: E-MEXP-3408 | ArrayExpress | 2011-12-07


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Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages.

Tolman Jennifer S JS   Valvano Miguel A MA  

BMC Genomics 20120209

BACKGROUND: Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in patients with cystic fibrosis. The bacterium survives within macrophages by interfering with endocytic trafficking and delaying the maturation of the B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia undergoes changes in gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation. RESULTS: We examined gene e  ...[more]

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