Transcriptomics

Dataset Information

6

Transcriptional profiling by array of human breast cancer cells (MDA-MB-231) grown in the presence or absence of 100nM Angiotensin II.


ABSTRACT: Human breast cancer cells (MDA-MB-231) were cultured in serum-free conditions and either left untreated or treated for 24h in presence of 100nM Angiotensin II. Total RNA was extracted using trizol and reverse transcribed prior to analysis.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Breast Cancer

SUBMITTER: Nicolas Cagnard  

PROVIDER: E-MEXP-3470 | ArrayExpress | 2012-12-05

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-3470.idf.txt Idf
E-MEXP-3470.raw.1.zip Raw
E-MEXP-3470.sdrf.txt Txt
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Publications


Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps of cancer metastasis, i.e. extravasation of circulating tumor cells and colonization of secondary organs. In this study, we investigated whether angiotensin II, a major vasoactive peptide both produced locally and released in the bloodstream, may trigger activating signals that contribute to cancer cell extravasation and metastasis. We used  ...[more]

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