Transcriptomics

Dataset Information

100

M-TraM Enterococcus faecium E1162 BHI and BHI with ampicillin


ABSTRACT: Mapping of transposon mutant library during growth in Brain Heart Infusion (BHI) broth and BHI broth with 20 ug/ml ampicillin

ORGANISM(S): Enterococcus faecium  

SUBMITTER: Xinglin Zhang  

PROVIDER: E-MEXP-3501 | ArrayExpress | 2012-10-09

REPOSITORIES: ArrayExpress

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Publications

Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.

Zhang Xinglin X   Paganelli Fernanda L FL   Bierschenk Damien D   Kuipers Annemarie A   Bonten Marc J M MJ   Willems Rob J L RJ   van Schaik Willem W  

PLoS genetics 20120628 6


Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to the β-lactam antibiotic ampicillin has become ubiquitous among clinical isolates. Mutations in the low-affinity penicillin binding protein PBP5 have previously been shown to be important for ampicillin resistance in E. faecium, but the existence of additional resistance determinants has been suggested. Here, we  ...[more]

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