Transcriptomics

Dataset Information

36

Transcription profiling by array of Bacillus cereus wild type and bc4707 deletion mutant after Bile Salts stress


ABSTRACT: Comparison of wild type Bacillus cereus ATCC14579 and its isogenic bc4707 deletion mutant under logarithmic growth (OD=0.5)

ORGANISM(S): Bacillus cereus  

SUBMITTER: Roger Simm   

PROVIDER: E-MEXP-3529 | ArrayExpress | 2014-05-02

REPOSITORIES: ArrayExpress

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Publications

BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance.

Simm Roger R   Vörös Aniko A   Ekman Jaakko V JV   Sødring Marianne M   Nes Ingerid I   Kroeger Jasmin K JK   Saidijam Massoud M   Bettaney Kim E KE   Henderson Peter J F PJ   Salkinoja-Salonen Mirja M   Kolstø Anne-Brit AB  

PloS one 20120516 5


Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more spe  ...[more]

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