Dataset Information


Transcription profiling by array of C. albicans SC5314 culture to investigate response to mannich ketones

ABSTRACT: An exponentially growing C. albicans SC5314 culture in SD medium at 30 C was split into two flasks, one exposed to MIC90 concentration of compound 2 (6.25 ug./ml-1)mannich ketones, the other to the same volume of water. Samples were collected after 30 and 60 min for transcript profiling.

ORGANISM(S): Candida albicans  

SUBMITTER: Tristan Rossignol  

PROVIDER: E-MEXP-3534 | ArrayExpress | 2012-09-28


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Antifungal activity of fused Mannich ketones triggers an oxidative stress response and is Cap1-dependent in Candida albicans.

Rossignol Tristan T   Kocsis Béla B   Bouquet Orsolya O   Kustos Ildikó I   Kilár Ferenc F   Nyul Adrien A   Jakus Péter B PB   Rajbhandari Kshitij K   Prókai László L   d'Enfert Christophe C   Lóránd Tamás T  

PloS one 20130430 4

We investigated the antifungal activity of fused Mannich ketone (FMK) congeners and two of their aminoalcohol derivatives. In particular, FMKs with five-membered saturated rings were shown to have minimum inhibitory concentration (MIC90s) ranging from 0.8 to 6 µg/mL toward C. albicans and the closely related C. parapsilosis and C. krusei while having reduced efficacy toward C. glabrata and almost no efficacy against Aspergillus sp. Transcript profiling of C. albicans cells exposed for 30 or 60 m  ...[more]

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