Dataset Information


Transcription profiling by array of Bacillus cereus ATCC14579 wild type response to bile salts stress

ABSTRACT: Comparison of the transcriptional response of B. cereus ATCC14579 before and after 15 min bile salts stress.

ORGANISM(S): Bacillus cereus  

SUBMITTER: Roger Simm  

PROVIDER: E-MEXP-3535 | ArrayExpress | 2012-01-31


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BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance.

Simm Roger R   Vörös Aniko A   Ekman Jaakko V JV   Sødring Marianne M   Nes Ingerid I   Kroeger Jasmin K JK   Saidijam Massoud M   Bettaney Kim E KE   Henderson Peter J F PJ   Salkinoja-Salonen Mirja M   Kolstø Anne-Brit AB  

PloS one 20120516 5

Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more spe  ...[more]

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