Dataset Information


Transcription profiling by array of Enterococcus faecium during mid-exponential growth phase in the presence and absence of ampicillin

ABSTRACT: Effect of 20 ug/ml ampicillin on gene expression of Enterococcus faecium E1162 during mid-exponential growth phase

ORGANISM(S): Enterococcus faecium  

SUBMITTER: Xinglin Zhang  

PROVIDER: E-MEXP-3564 | ArrayExpress | 2012-03-01


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Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.

Zhang Xinglin X   Paganelli Fernanda L FL   Bierschenk Damien D   Kuipers Annemarie A   Bonten Marc J M MJ   Willems Rob J L RJ   van Schaik Willem W  

PLoS genetics 20120628 6

Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to the β-lactam antibiotic ampicillin has become ubiquitous among clinical isolates. Mutations in the low-affinity penicillin binding protein PBP5 have previously been shown to be important for ampicillin resistance in E. faecium, but the existence of additional resistance determinants has been suggested. Here, we  ...[more]

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