Dataset Information


Transcription profiling by array of human KM-H2 HRS cell line treated with lestaurtinib

ABSTRACT: Effect of the tyrosine kinase inhibitor (TKI) lestaurtinib on Hodgkin and Reed/Sternberg (HRS) cell line KM-H2 compared to the solvent treated control.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Hodgkins Lymphoma

SUBMITTER: Meike S Holz  

PROVIDER: E-MEXP-3565 | ArrayExpress | 2012-02-21


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Induction of endoplasmic reticulum stress by sorafenib and activation of NF-κB by lestaurtinib as a novel resistance mechanism in Hodgkin lymphoma cell lines.

Holz Meike Stefanie MS   Janning Angela A   Renné Christoph C   Gattenlöhner Stefan S   Spieker Tilmann T   Bräuninger Andreas A  

Molecular cancer therapeutics 20121213 2

Hodgkin-Reed/Sternberg (HRS) cells of classical Hodgkin lymphoma show aberrant expression and activation of several receptor tyrosine kinases (RTK) in the majority of cases. Therefore, we tested whether tyrosine kinase inhibitors (TKI) already in clinical use or late stages of clinical trials have antiproliferative effects on HRS cell lines and evaluated the targets, affected signaling pathways, and mechanisms of cell death and resistance. Sorafenib and lestaurtinib had antiproliferative effects  ...[more]

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