Transcriptomics

Dataset Information

3

Transcription profiling by array of Saccharomyces cerevisiae to acetic acid-induced apoptosis


ABSTRACT: The initial translational response of the yeast Saccharomyces cerevisiae in response to acetic acid-induced apoptosis was investigated by microarray profiling of mRNAs contained in polysomal fractions obtained upon 0 (used as control), 15 and 30 minutes of acetic acid treatment. The mRNA fraction thus investigated corresponds to the mRNAs capable of overcoming the inhibition of cap-mediated translation initiation.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Laura Carreto  

PROVIDER: E-MEXP-3570 | ArrayExpress | 2013-02-24

REPOSITORIES: ArrayExpress

altmetric image

Publications

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid.

Silva Alexandra A   Sampaio-Marques Belém B   Fernandes Angela A   Fernandes Angela A   Carreto Laura L   Rodrigues Fernando F   Holcik Martin M   Santos Manuel A S MA   Ludovico Paula P  

PloS one 20130815 8


Acetic acid-induced apoptosis in yeast is accompanied by an impairment of the general protein synthesis machinery, yet paradoxically also by the up-regulation of the two isoforms of the heat shock protein 90 (HSP90) chaperone family, Hsc82p and Hsp82p. Herein, we show that impairment of cap-dependent translation initiation induced by acetic acid is caused by the phosphorylation and inactivation of eIF2α by Gcn2p kinase. A microarray analysis of polysome-associated mRNAs engaged in translation in  ...[more]

Similar Datasets

2017-02-23 | E-MTAB-5437 | ArrayExpress
2008-06-11 | E-GEOD-10091 | ArrayExpress
2015-06-28 | E-GEOD-65572 | ArrayExpress
2016-08-01 | E-GEOD-84746 | ArrayExpress
2015-06-04 | E-GEOD-67387 | ArrayExpress
2010-07-01 | E-MEXP-2740 | ArrayExpress
2012-03-28 | E-GEOD-29744 | ArrayExpress
2008-10-30 | E-GEOD-13410 | ArrayExpress
2014-02-01 | E-GEOD-43299 | ArrayExpress
2012-09-21 | E-GEOD-38707 | ArrayExpress