Dataset Information


Transcription profiling by array of Saccharomyces cerevisiae to acetic acid-induced apoptosis

ABSTRACT: The initial translational response of the yeast Saccharomyces cerevisiae in response to acetic acid-induced apoptosis was investigated by microarray profiling of mRNAs contained in polysomal fractions obtained upon 0 (used as control), 15 and 30 minutes of acetic acid treatment. The mRNA fraction thus investigated corresponds to the mRNAs capable of overcoming the inhibition of cap-mediated translation initiation.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Laura Carreto  

PROVIDER: E-MEXP-3570 | ArrayExpress | 2013-02-24


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Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid.

Silva Alexandra A   Sampaio-Marques Belém B   Fernandes Angela A   Fernandes Angela A   Carreto Laura L   Rodrigues Fernando F   Holcik Martin M   Santos Manuel A S MA   Ludovico Paula P  

PloS one 20130815 8

Acetic acid-induced apoptosis in yeast is accompanied by an impairment of the general protein synthesis machinery, yet paradoxically also by the up-regulation of the two isoforms of the heat shock protein 90 (HSP90) chaperone family, Hsc82p and Hsp82p. Herein, we show that impairment of cap-dependent translation initiation induced by acetic acid is caused by the phosphorylation and inactivation of eIF2α by Gcn2p kinase. A microarray analysis of polysome-associated mRNAs engaged in translation in  ...[more]

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