Transcriptomics

Dataset Information

3

Transcriptional profiling by array of human monocytes to study their involement in HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome at week 2 of combined antiretroviral threapy


ABSTRACT: Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) is a common complication in HIV-TB coinfected patients receiving combined antiretroviral therapy (cART). While monocytes/macrophages play major roles in both HIV- and TB-infection individually, a putative contribution of monocytes to the development of TB-IRIS remains unexamined. To investigate the possible functional contribution of monocytes to TB-IRIS pathogenesis, one of our first steps was to apply a genome-wide microarray analysis in monocytes of HIV-TB co-infected patients shortly after cART initiation. Based on the coparison of gene profiles between the TB-IRIS group and the control group, the modulated genes and pathways will be further investigated.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: THANH HUYEN T TRAN  

PROVIDER: E-MEXP-3591 | ArrayExpress | 2013-07-08

REPOSITORIES: ArrayExpress

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