Transcriptomics

Dataset Information

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Transcription profiling by array of mouse primary hematopoietic precursor cells transformed by two different HOX genes (HOXA1 and HOXA9) and by two HOX derivatives where the homeodomain was exchanged.


ABSTRACT: The gene expression profile was determined in primary cells transformed by two different HOX genes (HOXA1 and HOXA9) and by two HOX derivatives where the homeodomain was exchanged.

ORGANISM(S): Mus musculus  

SUBMITTER: Robert K Slany   

PROVIDER: E-MEXP-3617 | ArrayExpress | 2013-01-31

REPOSITORIES: ArrayExpress

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Publications

The homeodomain region controls the phenotype of HOX-induced murine leukemia.

Breitinger Constanze C   Maethner Emanuel E   Garcia-Cuellar Maria-Paz MP   Slany Robert K RK  

Blood 20120918 19


HOX proteins are widely involved in hematopoietic development. These transcription factors combine a conserved DNA-binding homeobox with a divergent N-terminus that mediates interaction with variable cofactors. The resulting combinatorial diversity is thought to be responsible for mammalian HOX specificity. Contrasting this proposed mechanism for normal HOX function, here we demonstrate that, in the context of hematopoietic immortalization and leukemogenesis, individual HOX properties are govern  ...[more]

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