Transcriptomics

Dataset Information

6

Transcription profiling by array of human white blood cells of patients with nosocomial sepsis to investigate immunologic alterations taking place


ABSTRACT: To investigate immunologic alterations taking place in patients with nosocomial sepsis, we undertook genomic expression analysis of white blood cells (WBC) using DNA microarrays in a small sample of trauma patients who developed severe sepsis/septic shock during their ICU stay and compared with trauma patients with uncomplicated sepsis. RNA was extracted from blood obtained upon admission (a) and at the onset of the disease (b).

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Normal,Ards

SUBMITTER: Vaggelis Harokopos  

PROVIDER: E-MEXP-3621 | ArrayExpress | 2012-08-01

REPOSITORIES: ArrayExpress

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Publications

Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.

Vassiliou Alice G AG   Maniatis Nikolaos A NA   Orfanos Stylianos E SE   Mastora Zafeiria Z   Jahaj Edison E   Paparountas Triantafillos T   Armaganidis Apostolos A   Roussos Charis C   Aidinis Vassilis V   Kotanidou Anastasia A  

Critical care (London, England) 20130912 5


INTRODUCTION: Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or severe sepsis and acute respiratory distress syndrome (n = 3). By comparing our results with published expression profiling studies in animal models of sepsis and lung injury, we found aquaporin-1 to be differentially expressed across all studies. Our aim was to determine how the water  ...[more]

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