Dataset Information


Comparative genomic hybridization by array of Enterococcus faecium grown in BHI broth or BHI broth with 0.02% bile salts to identify genetic loci required for bile salts resistance

ABSTRACT: A genome-wide identification of the genetic loci required for bile salts resistance in E. faecium

ORGANISM(S): Enterococcus faecium  

SUBMITTER: Xinglin Zhang  

PROVIDER: E-MEXP-3797 | ArrayExpress | 2013-10-10


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Functional genomic analysis of bile salt resistance in Enterococcus faecium.

Zhang Xinglin X   Bierschenk Damien D   Top Janetta J   Anastasiou Iacovos I   Bonten Marc J M MJ   Willems Rob J L RJ   van Schaik Willem W  

BMC genomics 20130503

BACKGROUND: Enterococcus faecium is a Gram-positive commensal bacterium of the mammalian intestinal tract. In the last two decades it has also emerged as a multi-resistant nosocomial pathogen. In order to survive in and colonize the human intestinal tract E. faecium must resist the deleterious actions of bile. The molecular mechanisms exploited by this bacterium to tolerate bile are as yet unexplored. RESULTS: In this study we used a high-throughput quantitative screening approach of transposon  ...[more]

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