Dataset Information


Transcription profiling of mouse macrophage responses to lipopolysaccharide (LPS) and 12-o-tetradecanoylphorbol-13-acetate (TPA) in wild type and NcoR-/- mice

ABSTRACT: Comparison of mouse macrophage responses to lipopolysaccharide (LPS) and 12-o-tetradecanoylphorbol-13-acetate (TPA) between wild-type and NcoR-/- mice.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Sumito S Ogawa   Christopher C Glass  Kristen K Jepsen  Dominique D Sawka-Verhelle  Jean Lozach  Randall R Johnson  Michael M Rosenfeld  Roman R Sasik 

PROVIDER: E-MEXP-38 | ArrayExpress | 2006-11-06


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A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.

Ogawa Sumito S   Lozach Jean J   Jepsen Kristen K   Sawka-Verhelle Dominique D   Perissi Valentina V   Sasik Roman R   Rose David W DW   Johnson Randall S RS   Rosenfeld Michael G MG   Glass Christopher K CK  

Proceedings of the National Academy of Sciences of the United States of America 20040927 40

The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of multiprotein complexes that mediate active repression by unliganded nuclear receptors. Recent studies suggest that NCoR and SMRT can interact with and exert repressive effects on several other classes of DNA-binding transcription factors, but the physiological importance of these interactions has not been established. Here, in  ...[more]

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