Dataset Information


Transcription profiling by array of adult and juvenile zebrafish to investigate gonad differentiation

ABSTRACT: Zebrafish males undergo a juvenile ovary to testis type gonadal transformation process. To understand how juvenile ovary-to-testis transformation in zebrafish is genetically regulated, we compared the transcriptomes of juvenile ovary (JO) and juvenile ovotestis (JOT) samples at 35 dpf using the Gonad Uniclone Microarray v1 (ArrayExpress ID: A-MEXP-838). We also analyzed the transcriptomes of the 32 dpf JO, 32 dpf JOT, 34 dpf JOT, and 36 dpf JOT gonads using the slightly modified Gonad Uniclone Microarray v2 and together with the 35 dpf JO and 35 dpf JOT samples, compared the JO samples against the JOT samples to identify genes that could be potentially involved in the gonad transformation process.

ORGANISM(S): Danio rerio  

SUBMITTER: Junhui Jiang  

PROVIDER: E-MEXP-3879 | ArrayExpress | 2013-12-27


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Gonad differentiation in zebrafish is regulated by the canonical Wnt signaling pathway.

Sreenivasan Rajini R   Jiang Junhui J   Wang Xingang X   Bártfai Richárd R   Kwan Hsiao Yuen HY   Christoffels Alan A   Orbán László L  

Biology of reproduction 20140227 2

Zebrafish males undergo a "juvenile ovary-to-testis" gonadal transformation process. Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Müllerian hormone (amh), and pathways such as Tp53-mediated germ-cell apoptosis have been implicated in zebrafish testis formation. However, our knowledge of the regulation of this complex process is incomplete, and much remains to be investigated about the molecular pathways and network of genes that control it. Using a microarray-ba  ...[more]

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