Dataset Information


Transcription profiling of two mouse myc mutants Eilers-Mouse-MycKR6 vs Mycwt

ABSTRACT: Comparison gene regulation by two different Myc mutants

INSTRUMENT(S): (Make:Perkin Elmer,Model:ScanArray Express)

ORGANISM(S): Mus musculus  

SUBMITTER: Maria Capra   Sovana Adhikary  Martin Scheffner  Kristian Helin  Ulrike Kogel  Stephan Goettig  Rudi Beier  Sandra Bernard  Martin Eilers  Federica Marinoni 

PROVIDER: E-MEXP-407 | ArrayExpress | 2005-10-17


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The Myc oncoprotein forms a binary activating complex with its partner protein, Max, and a ternary repressive complex that, in addition to Max, contains the zinc finger protein Miz1. Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain. Miz1 inhibits this ubiquitination. HectH9-mediated ubiquitination of Myc is required for transactivation of multiple target genes, recruitment of the coactivator p300, and inductio  ...[more]

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