Transcriptomics

Dataset Information

7

Transcription profiling of mouse XX and XY somatic gonadal compartment during sex determination


ABSTRACT: Expression profiles of XX and XY somatic gonadal compartment during sex determination. This experiment was updated in March 2011 to correct the incorrect age value for sample Female E10.5_6 (was 11 days should be 10.5).

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Olivier Schaad  

PROVIDER: E-MEXP-454 | ArrayExpress | 2006-01-01

REPOSITORIES: ArrayExpress

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Publications

Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.

Nef Serge S   Schaad Olivier O   Stallings Nancy R NR   Cederroth Christopher R CR   Pitetti Jean-Luc JL   Schaer Guillaume G   Malki Safia S   Dubois-Dauphin Michel M   Boizet-Bonhoure Brigitte B   Descombes Patrick P   Parker Keith L KL   Vassalli Jean-Dominique JD  

Developmental biology 20051007 2


The primary event in mammalian sexual development is the differentiation of the bipotential gonads into either testes or ovaries. Our understanding of the molecular pathways specifying gonadal differentiation is still incomplete. To identify the initial molecular changes accompanying gonadal differentiation in mice, we have performed a large-scale transcriptional analysis of XX and XY Sf1-positive gonadal cells during sex determination. In both male and female genital ridges, a robust genetic pr  ...[more]

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