Transcriptomics

Dataset Information

8

Transcription profiling of hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia


ABSTRACT: Hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice were subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia.

INSTRUMENT(S): 428 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: John P Headrick   Kevin J Ashton  Kirsty Holmgren  Laura Willems  Linda Ferreira 

PROVIDER: E-MEXP-496 | ArrayExpress | 2005-12-31

REPOSITORIES: ArrayExpress

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Publications

Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress.

Ashton Kevin J KJ   Willems Laura L   Holmgren Kirsty K   Ferreira Linda L   Headrick John P JP  

Experimental gerontology 20051215 2


Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays and quantitative RT-PCR we characterized shifts in gene expression patterns with aging in normoxic and post-ischemic (20 min global ischemia, 60 min reperfusion) murine hearts (young: 2-4 months; aged: 16-18 months). We identified an age-associated up-regulation of transcripts involved in cell death,  ...[more]

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