Dataset Information


Transcription profiling of fission yeast cell cycle, cdc25 sep1 block and release

ABSTRACT: Cell cycle timecourse of fission yeast using a whole-culture (temperature sensitive mutant cdc25) synchronisation method in a sep1 deletion background

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Juan Mata   Chris J Penkett  Jacky Hayles  Pietro Lio  Gabriella Rustici  Katja Kivinen  Gavin Burns  Paul Nurse  Alvis Brazma  Jurg Bahler 

PROVIDER: E-MEXP-61 | ArrayExpress | 2004-04-01


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Cell-cycle control of transcription seems to be universal, but little is known about its global conservation and biological significance. We report on the genome-wide transcriptional program of the Schizosaccharomyces pombe cell cycle, identifying 407 periodically expressed genes of which 136 show high-amplitude changes. These genes cluster in four major waves of expression. The forkhead protein Sep1p regulates mitotic genes in the first cluster, including Ace2p, which activates transcription in  ...[more]

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