Transcriptomics

Dataset Information

61

Transcription profiling of fission yeast cell cycle, cell cycle overexpressions


ABSTRACT: Cell cycle regulation in fission yeast using overexpression of transcription factors

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Juan Mata   Jacky Hayles  Chris J Penkett  Pietro Lio  Gabriella Rustici  Katja Kivinen  Alvis Brazma  Gavin Burns  Paul Nurse  Jurg Bahler 

PROVIDER: E-MEXP-63 | ArrayExpress | 2004-04-01

REPOSITORIES: ArrayExpress

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Publications


Cell-cycle control of transcription seems to be universal, but little is known about its global conservation and biological significance. We report on the genome-wide transcriptional program of the Schizosaccharomyces pombe cell cycle, identifying 407 periodically expressed genes of which 136 show high-amplitude changes. These genes cluster in four major waves of expression. The forkhead protein Sep1p regulates mitotic genes in the first cluster, including Ace2p, which activates transcription in  ...[more]

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