Transcriptomics

Dataset Information

125

Transcription profiling of C. elegans after infection with Microbacterium nematophilum


ABSTRACT: Genomic response of C. elegans after infection with Microbacterium nematophilum.

The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres to the rectal and post-anal cuticle of the worm, causing slowed growth, constipation, and a defensive swelling response of rectal hypodermal cells. To explore the genomic responses that the worm activates after pathogenic attack we used microarray analysis of transcriptional changes induced after 6 hr infection, comparing virulent with avirulent infection.

REANALYSED by: E-MEXP-696

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Dilair Baban   Delia M O'Rourke  Richard Mott  Jonathan Hodgkin  Maria Demidova 

PROVIDER: E-MEXP-696 | ArrayExpress | 2005-01-01

REPOSITORIES: ArrayExpress

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Publications

Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.

O'Rourke Delia D   Baban Dilair D   Demidova Maria M   Mott Richard R   Hodgkin Jonathan J  

Genome research 20060629 8


The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres to the rectal and post-anal cuticle of the worm, causing slowed growth, constipation, and a defensive swelling response of rectal hypodermal cells. To explore the genomic responses that the worm activates after pathogenic attack we used microarray analysis of transcriptional changes indu  ...[more]

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