Transcriptomics

Dataset Information

22

Chromatin immunoprecipitation of ATF3-/- mouse bone marrow macrophages with and without stimulation with lipopolysaccharide for 1 or 2 hours


ABSTRACT: DNA binding determination for ATF3 -/- macrophages without stimulation and with stimulation by LPS after 1 or 2 hours.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Martin Korb   Twonsin Hai  Alistair G Rust  Mark Gilchrist  Kathleen Kennedy  Vesteinn Thorsson  Hamid Bolouri  Bruz Marzolf  Alan Aderem  Bin Li 

PROVIDER: E-MEXP-730 | ArrayExpress | 2006-07-07

REPOSITORIES: ArrayExpress

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Publications

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

Gilchrist Mark M   Thorsson Vesteinn V   Li Bin B   Rust Alistair G AG   Korb Martin M   Roach Jared C JC   Kennedy Kathleen K   Hai Tsonwin T   Bolouri Hamid H   Aderem Alan A  

Nature 20060501 7090


The innate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammatory disease. This control is mediated, in part, by cytokines that are secreted by macrophages. Immune regulation is extraordinarily complex, and can be best investigated with systems approaches (that is, using computational tools to predict regulatory networks arising from global, high-throughput data sets). Here we use cluster analysis of a comprehensive set of transcriptomic data derived f  ...[more]

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