Transcriptomics

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Transcription profiling of camptothecin treatment time series performed on human U87 glioma cells


ABSTRACT: Time-series analysis of camptothecin effects on U87 glioma cells

INSTRUMENT(S): DNA Microarray Scanner BA [Agilent Technologies]

ORGANISM(S): Homo sapiens  

SUBMITTER: Elena Morandi  

PROVIDER: E-MEXP-741 | ArrayExpress | 2006-09-30

REPOSITORIES: ArrayExpress

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Publications


BACKGROUND: The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptothecin outcome in this type of cancer cells. To address this issue, we had previously compared the expression profile of human U87-MG glioblastoma cells with that of a CPT-resistant co  ...[more]

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