Transcriptomics

Dataset Information

4

Transcription profiling of mouse splenic B cells expressing a dominant-negative p300 allele which lacks histone acetyltransferase activity


ABSTRACT: The p300 protein is one of more than 15 known mammalian HATs. We have used mice that carry a mutant allele of the p300 gene, which encodes a full-length protein that, however, lacks detectable acetyltransferase (AT)-activity and that acts in a dominant-negative manner. In addition, the allele is conditional, so that it can be expressed in a tissue-specific manner with the help of mice that express Cre-recombinase. Expression of the mutant allele specifically in B-cells, using CD19-cre mice, results in premature death with full penetrance from an autoimmune disease that closely mimics systemic lupus erythematosus (SLE) in its pathological manifestations.

INSTRUMENT(S): ScanArray Express HT [PerkinElmer]

ORGANISM(S): Mus musculus  

DISEASE(S): Mild Sle-like Autoimmune Disease,Normal

SUBMITTER: Werner Lutz  

PROVIDER: E-MEXP-747 | ArrayExpress | 2006-07-01

REPOSITORIES: ArrayExpress

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