Transcriptomics

Dataset Information

6

Transcription profiling of mouse embryonic stem cell differentiation following treatment with DKK1


ABSTRACT: Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Kenneth M Murphy   Ken M Murphy  R. Coleman Lindsley  Jennifer G Gill 

PROVIDER: E-MEXP-759 | ArrayExpress | 2006-12-31

REPOSITORIES: ArrayExpress

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Publications

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.

Jenner Richard G RG   Townsend Michael J MJ   Jackson Ian I   Sun Kaiming K   Bouwman Russell D RD   Young Richard A RA   Glimcher Laurie H LH   Lord Graham M GM  

Proceedings of the National Academy of Sciences of the United States of America 20091005 42


Upon detection of antigen, CD4(+) T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes are known for these two factors and because of this, the mechanism through which T-bet and GATA-3 induce differentiation toward alternative cell fates is not fully understood. Here, we provide a geno  ...[more]

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