Dataset Information


Transcription profiling of homozygous Commd1 null mouse embryos to elucidate the underlying mechanism leading to embryonic lethality

ABSTRACT: A gene expression study using microarray analysis was performed to elucidate the underlying mechanism leading to embryonic lethality in homozygous Commd1 null (Commd1-/-) mouse embryos. A gene expression profile of 9.5 dpc Commd1-/- embryos were generated and were compared to a gene expression profile of both 8.5 dpc and 9.5 dpc normal embryos.

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Mus musculus  

DISEASE(S): Embryonic Lethal At Day 8.5 To 9.5,Normal

SUBMITTER: Amy Chen   Karen Duran  Cisca Wijmenga  Paul Liu  Patricia muller  Bart van de Sluis  Leo Klomp 

PROVIDER: E-MEXP-832 | ArrayExpress | 2006-09-01


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Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.

van de Sluis Bart B   Muller Patricia P   Duran Karen K   Chen Amy A   Groot Arjan J AJ   Klomp Leo W LW   Liu Paul P PP   Wijmenga Cisca C  

Molecular and cellular biology 20070319 11

COMMD1 (previously known as MURR1) belongs to a novel family of proteins termed the copper metabolism gene MURR1 domain (COMMD) family. The 10 COMMD family members are well conserved between vertebrates, but the functions of most of the COMMD proteins are unknown. We recently established that COMMD1 is associated with the hepatic copper overload disorder copper toxicosis in Bedlington terriers. Recent in vitro studies indicate that COMMD1 has multiple functions, including sodium transport and NF  ...[more]

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