Dataset Information


Transcription profiling of mouse fibroblast-like cells infected with mouse hepatitis virus

ABSTRACT: Effect of mouse hepatitis virus strain A59 replication on gene expression and mRNA stability in LR cells

INSTRUMENT(S): G2565AA DNA microarray scanner [Agilent]

ORGANISM(S): Mus musculus  

SUBMITTER: Cornelis A.M. de Haan   Peter J.M. Rottier  Marian Groot Koerkamp  Matthijs Raaben 

PROVIDER: E-MEXP-895 | ArrayExpress | 2007-11-13


altmetric image


Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies.

Raaben Matthijs M   Groot Koerkamp Marian J A MJ   Rottier Peter J M PJ   de Haan Cornelis A M CA  

Cellular microbiology 20070508 9

Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress respons  ...[more]

Similar Datasets

2015-10-22 | E-MEXP-3715 | ExpressionAtlas
2008-06-16 | E-GEOD-8640 | ArrayExpress
2009-10-01 | E-MEXP-2081 | ArrayExpress
2011-01-12 | E-TABM-1209 | ArrayExpress
2016-01-05 | E-TABM-82 | ExpressionAtlas
2015-12-04 | E-TABM-142 | ExpressionAtlas
2012-10-31 | E-MEXP-3715 | ArrayExpress
2014-06-19 | E-GEOD-58630 | ArrayExpress
2006-10-23 | E-TABM-114 | ArrayExpress
2013-03-21 | E-MTAB-1448 | ArrayExpress