Transcriptomics

Dataset Information

14

Transcription profiling by array of hippocampi from rats after treatment with scopolamine and stimulation in a spatial memory task


ABSTRACT: Hippocampal gene expression profiling in scopolamine treated adult rats following stimulation in a spatial memory task

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Rémi R Quirion   Jonathan Brouillette 

PROVIDER: E-MEXP-920 | ArrayExpress | 2006-12-30

REPOSITORIES: ArrayExpress

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Publications

Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.

Brouillette Jonathan J   Young Deborah D   During Matthew J MJ   Quirion Rémi R  

Journal of neurochemistry 20070601 6


Scopolamine-treated rats are commonly used as a psychopharmacological model of memory dysfunction and have been extensively studied to establish the effectiveness of acetylcholinesterase inhibitors in the treatment of Alzheimer's disease. Scopolamine is a muscarinic acetylcholine receptor antagonist that induces memory deficits in young subjects similar to those occurring during aging. The amnesic effect of scopolamine is well established but the molecular and cellular mechanisms that sustain it  ...[more]

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