Transcriptomics

Dataset Information

10

Transcription profiling of mouse epidermal cells sorted into three populations based on alpha 6 integrin, CD34 or Sca-1 surface marker expression


ABSTRACT: Epidermal keratinocytes were isolated from adult murine skin and FACS sorted into three populations based on their surface maker expression of alpha 6 integrin, CD34 and Sca-1.
- Alpha 6 positive cells constitute the entire population of basal or proliferative keratinocytes from the interfollicular epidermis and hair follicle. Both BIB and Bulge cells are contained within the total population of alpha 6 positive cells.
- BIB cells reside in the hair follicle in a region between the infundibulum and bulge and these cells are characterized by low alpha 6 integrin surface levels and are negative for CD34 and Sca-1 surface proteins.
- Bulge cells are derived from the bulge region of the hair follicle and are characterized by low + high alpha 6 integrin surface levels and are positive for CD34 but negative for Sca-1.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: David M Owens   Charlotte Triel  Xiaohong Yan  Uffe B Jensen 

PROVIDER: E-MEXP-928 | ArrayExpress | 2009-11-16

REPOSITORIES: ArrayExpress

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Publications

A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus.

Jensen Uffe Birk UB   Yan Xiaohong X   Triel Charlotte C   Woo Seung-Hyun SH   Christensen Rikke R   Owens David M DM  

Journal of cell science 20080205 Pt 5


The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent capacity; however, the restricted contributions of these cells under homeostatic conditions indicates that additional stem or progenitor cell populations may be required to maintain squamous and sebaceous lineages. We have identified a distinct population of murine hair follicle keratinocytes residing in the upper isthmus (UI) between the infundibulum and bulge regions that are distinguished by low alph  ...[more]

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