Transcriptomics

Dataset Information

44

Transcription profiling by array of undifferentiated and differentiated human soft tissue sarcomas isolated from adipose tissue


ABSTRACT: Comparative analysis of undifferentiated and well-differentiated human soft tissue sarcomas

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Alain AURIAS  

PROVIDER: E-MEXP-964 | ArrayExpress | 2007-03-31

REPOSITORIES: ArrayExpress

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Publications

JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas.

Mariani Odette O   Brennetot Caroline C   Coindre Jean-Michel JM   Gruel Nadège N   Ganem Carine C   Delattre Olivier O   Stern Marc-Henri MH   Aurias Alain A  

Cancer cell 20070401 4


The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a human cancer. We demonstrate here that it is highly amplified and overexpressed in undifferentiated and aggressive human sarcomas, which are blocked at an early step of adipocyte differentiation. We c  ...[more]

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