Dataset Information


Transcription profiling of human CD8 T cells activated with CD3 or CD3-CD28 prior to retroviral transduction and different selection procedures (G418 or NGFR-MACS)n

ABSTRACT: effect of different T cell activations (CD3 and CD3-CD28) prior retroviral transduction and different selection procedures (G418 or NGFR-MACS)

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  


PROVIDER: E-MEXP-973 | ArrayExpress | 2007-06-01


altmetric image


Transcriptome of retrovirally transduced CD8+ lymphocytes: influence of cell activation, transgene integration, and selection process.

Deschamps Marina M   Robinet Eric E   Certoux Jean Marie JM   Mercier Patricia P   Sauce Delphine D   De Vos John J   Montcuquet Nicolas N   Bonyhadi Mark M   Rème Thierry T   Tiberghien Pierre P   Ferrand Christophe C  

Molecular immunology 20070910 4

A suicide gene introduced by retroviral means can allow in vivo control of alloreactivity mediated by donor gene-modified T cells (GMTC) after allogeneic hematopoietic stem cell transplantation. The present study establishes the transcriptomic profile of GMTC prepared according to the GMTC production process used in our clinical trial (activation/selection methods, CD3/NeoR), which was previously demonstrated to induce phenotypical and functional alterations. This transcriptomic profile was comp  ...[more]

Similar Datasets

2009-01-17 | E-GEOD-14330 | ArrayExpress
2012-11-05 | E-GEOD-25252 | ArrayExpress
2015-10-28 | E-GEOD-66147 | ArrayExpress
2015-10-28 | E-GEOD-66146 | ArrayExpress
2013-12-20 | E-GEOD-53514 | ArrayExpress
2016-09-24 | E-MTAB-4561 | ArrayExpress
2008-10-21 | E-GEOD-12396 | ArrayExpress
2019-06-22 | E-MTAB-5493 | ArrayExpress
2008-04-04 | E-GEOD-7345 | ArrayExpress
2013-10-17 | E-GEOD-49019 | ArrayExpress