Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo Sapiens
DISEASE(S): Sars-cov-2 Infection,Normal
SUBMITTER: Joshua Rosenheim
PROVIDER: E-MTAB-10022 | ArrayExpress | 2021-07-07
REPOSITORIES: ArrayExpress
Gupta Rishi K RK Rosenheim Joshua J Bell Lucy C LC Chandran Aneesh A Guerra-Assuncao Jose A JA Pollara Gabriele G Whelan Matthew M Artico Jessica J Joy George G Kurdi Hibba H Altmann Daniel M DM Boyton Rosemary J RJ Maini Mala K MK McKnight Aine A Lambourne Jonathan J Cutino-Moguel Teresa T Manisty Charlotte C Treibel Thomas A TA Moon James C JC Chain Benjamin M BM Noursadeghi Mahdad M
The Lancet. Microbe 20210706 10
<h4>Background</h4>We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the diagnostic accuracy of existing candidate whole-blood transcriptomic signatures for viral infection to predict positivity of nasopharyngeal SARS-CoV-2 PCR testing.<h4>Methods</h4>We did a nested case-control diagnostic accuracy study among a prospect ...[more]