Transcriptomics

Dataset Information

0

All-trans retinoic reduces the levels of cardiolipins in the NB4 acute promyelocytic leukemia cell-line affecting the autophagy and differentiation responses


ABSTRACT: All-trans retinoic (ATRA) is used in the treatment of acute promyelocytic leukemia a rare form of AML characterized by the presence of a specific translocation involving chrosomes 15;17 and causing the production of the PML-RARα fusion protein in 95% of the cases. ATRA differentiates the APL blasts into neutrophilic granulocytes which are short lived cells. This effect is at the basis of the therapeutic effect of ATRA.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens  

DISEASE(S): Acute Promyelocytic Leukemia

SUBMITTER: MARCO BOLIS   Luca Guarrera  

PROVIDER: E-MTAB-10267 | ArrayExpress | 2022-01-31

SECONDARY ACCESSION(S): ERP127841

REPOSITORIES: ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-MTAB-10267.idf.txt Idf
E-MTAB-10267.idf.txt_original Idf
E-MTAB-10267.sdrf.txt Txt
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