Transcriptomics

Dataset Information

298

Transcription profiling by high throughput sequencing of liver from SHR/OlaIpcv and BN-Lx/Cub rats

ABSTRACT: RNA-seq liver SHR/OlaIpcv and BN-Lx/Cub to investigate the effect of genetic backgound on the transcriptome

INSTRUMENT(S): AB SOLiD

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Marieke Simonis  

PROVIDER: E-MTAB-1029 | ArrayExpress | 2012-04-01

SECONDARY ACCESSION(S): ERP001295

REPOSITORIES: ArrayExpress, ENA

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Publications

Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel.

Simonis Marieke M   Atanur Santosh S SS   Linsen Sam S   Guryev Victor V   Ruzius Frans-Paul FP   Game Laurence L   Lansu Nico N   de Bruijn Ewart E   van Heesch Sebastiaan S   Jones Steven J M SJ   Pravenec Michal M   Aitman Tim J TJ   Cuppen Edwin E  

Genome Biology 20120427 4

BACKGROUND:With the advent of next generation sequencing it has become possible to detect genomic variation on a large scale. However, predicting which genomic variants are damaging to gene function remains a challenge, as knowledge of the effects of genomic variation on gene expression is still limited. Recombinant inbred panels are powerful tools to study the cis and trans effects of genetic variation on molecular phenotypes such as gene expression. RESULTS:We generated a comprehensive invento  ...[more]

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