Transcriptomics

Dataset Information

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Single-cell transcriptional landscape of human embryonic limb development - Mouse


ABSTRACT: To investigate into the evolutionary conversation of the single-cell transcriptome of human fetal limbs, especially the principles of forelimb and hindlimb specification and proximal-distal axis establishment, we collected the forelimbs and hindlimbs of mouse embryos matching human samples. We dissected the limbs to separate proximal, middle and distal parts and generated single-cell RNA-seq data of more than 70,000 cells. Combining this dataset with our human data, we are able to see highly conserved limb cell types and limb axis drivers.

INSTRUMENT(S): Illumina NovaSeq 6000

TISSUE(S): Hindlimb Zeugopod, Forelimb Stylopod, Hindlimb Autopodium, Forelimb Autopodium, Forelimb Zeugopod, Hindlimb Stylopod

DISEASE(S): Normal

SUBMITTER: Peng He   Bao Zhang   Sarah A Teichmann   Hongbo Zhang   John Lawrence   Shuaiyu Wang  

PROVIDER: E-MTAB-10514 | ArrayExpress | 2022-04-15

SECONDARY ACCESSION(S): ERP129376

REPOSITORIES: ArrayExpress, ENA

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