Single-cell transcriptional landscape of human embryonic limb development - Mouse
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ABSTRACT: To investigate into the evolutionary conversation of the single-cell transcriptome of human fetal limbs, especially the principles of forelimb and hindlimb specification and proximal-distal axis establishment, we collected the forelimbs and hindlimbs of mouse embryos matching human samples. We dissected the limbs to separate proximal, middle and distal parts and generated single-cell RNA-seq data of more than 70,000 cells. Combining this dataset with our human data, we are able to see highly conserved limb cell types and limb axis drivers.
INSTRUMENT(S): Illumina NovaSeq 6000
TISSUE(S): Hindlimb Zeugopod, Forelimb Stylopod, Hindlimb Autopodium, Forelimb Autopodium, Forelimb Zeugopod, Hindlimb Stylopod
DISEASE(S): Normal
SUBMITTER:
Peng He
Bao Zhang
Sarah A Teichmann
Hongbo Zhang
John Lawrence
Shuaiyu Wang
PROVIDER: E-MTAB-10514 | ArrayExpress | 2022-04-15
SECONDARY ACCESSION(S): ERP129376
REPOSITORIES: ArrayExpress, ENA
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