Transcriptomics

Dataset Information

245

MicroRNA profiling of ovary cell tumors and HOSE cells


ABSTRACT: In order to determine the difference at the microRNA level of different ovarian tumor histotypes, we have performed a whole miRNA screening on 183 patients of grade 1 ovarian cancer. Additionally, we compared the miRNA profile of tumors with standard ovarian epithelial cells (HOSE).

ORGANISM(S): Homo sapiens  

SUBMITTER: Luca Beltrame  

PROVIDER: E-MTAB-1067 | ArrayExpress | 2013-06-17

REPOSITORIES: ArrayExpress

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Publications

Wiring miRNAs to pathways: a topological approach to integrate miRNA and mRNA expression profiles.

Calura Enrica E   Martini Paolo P   Sales Gabriele G   Beltrame Luca L   Chiorino Giovanna G   D'Incalci Maurizio M   Marchini Sergio S   Romualdi Chiara C  

Nucleic acids research 20140506 11


The production rate of gene expression data is nothing less than astounding. However, with the benefit of hindsight we can assert that, since we completely ignored the non-coding part of the transcriptome, we spent the last decade to study cell mechanisms having few data in our hands. In this scenario, microRNAs, which are key post-trascriptional regulators, deserve special attention. Given the state of knowledge about their biogenesis, mechanisms of action and the numerous experimentally valida  ...[more]

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