Transcriptomics

Dataset Information

58

MicroRNA profiling by array of human osteosarcoma and their normal bone counterpart


ABSTRACT: Profiling array: in order to investigate the microRNAs differentially expressed between osteosarcoma and their normal bone counterpart. Specimens were kept at 4 C in RNAlater for up to 1 week, then stored at 80 C. When formal pathologic interpretation of histology from other portions of the biopsy specimen rendered a diagnosis of osteosarcoma, the RNA-preserving tissue specimens were banked and annotated. In preparation for these specific experiments, total RNA was extracted from banked specimens with the TRIzol reagent and method (Invitrogen). Control samples were derived from to-be-discarded bone fragments obtained from similarly consented patients undergoing debridement surgeries for acute, traumatic injuries to the long bones.

OTHER RELATED OMICS DATASETS IN: E-MEXP-3628

ORGANISM(S): Homo sapiens  

DISEASE(S): Osteosarcoma,Normal

SUBMITTER: Marco Galasso  

PROVIDER: E-MTAB-1136 | ArrayExpress | 2012-05-21

REPOSITORIES: ArrayExpress

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Publications

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells.

Salah Zaidoun Z   Arafeh Rand R   Maximov Vadim V   Galasso Marco M   Khawaled Saleh S   Abou-Sharieha Samah S   Volinia Stefano S   Jones Kevin B KB   Croce Carlo M CM   Aqeilan Rami I RI  

Oncotarget 20150301 7


Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults. The essential mechanisms underlying osteosarcomagenesis and progression continue to be obscure. MicroRNAs (miRNAs) have far-reaching effects on the cellular biology of development and cancer. We recently reported that unique miRNA signatures associate with the pathogenesis and progression of OS. Of particular interest, we found that higher expression of miR-27a is associated with clinical metastati  ...[more]

Publication: 1/2

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