Transcriptomics

Dataset Information

239

Transcription profiling by array of Ovis aries mesenteric lymph nodes from naturally scrapie infected and control sheep


ABSTRACT: Comparison of genomic expression profiles in the mesenteric lymph nodes of naturally scrapie infected (clinical and preclinical stages) and control sheep. Expression profiles comparison of 7 clinical and 4 preclinical naturally scrapie infected sheep and 6 controls.

ORGANISM(S): Ovis aries  

DISEASE(S): Normal,Scrapie Infected

SUBMITTER: Hicham Filali  

PROVIDER: E-MTAB-1346 | ArrayExpress | 2013-10-29

REPOSITORIES: ArrayExpress

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Publications

Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie.

Filali Hicham H   Martín-Burriel Inmaculada I   Harders Frank F   Varona Luis L   Hedman Carlos C   Mediano Diego R DR   Monzón Marta M   Bossers Alex A   Badiola Juan J JJ   Bolea Rosa R  

BMC genomics 20140123


BACKGROUND: Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system. Although prions multiply/accumulate in the lymph nodes without any detectable pathology, transcriptional changes in this tissue may reflect biological processes that contribute to the molecular pathogenesis of prion diseases. Little is known about the molecular processes that occur in the lymphoreticular system in early and late stages of prion dis  ...[more]

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